Predicting the Risk of Recurrent Venous Thromboembolism: Current Challenges and Future Opportunities

Journal of Clinical Medicine

Karlheinz Peter¹  James McFadyen²  Hannah Stevens²  Huyen Tran² 

[1] Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia;Clinical Haematology Department, Alfred Hospital, Melbourne, VIC 3004, Australia;

关键词: venous thromboembolism;    pulmonary embolism;    deep vein thrombosis;    biomarker;    risk stratification;   

DOI  :  10.3390/jcm9051582

来源: DOAJ

【 摘 要 】

Acute venous thromboembolism (VTE) is a commonly diagnosed condition and requires treatment with anticoagulation to reduce the risk of embolisation as well as recurrent venous thrombotic events. In many cases, cessation of anticoagulation is associated with an unacceptably high risk of recurrent VTE, precipitating the use of indefinite anticoagulation. In contrast, however, continuing anticoagulation is associated with increased major bleeding events. As a consequence, it is essential to accurately predict the subgroup of patients who have the highest probability of experiencing recurrent VTE, so that treatment can be appropriately tailored to each individual. To this end, the development of clinical prediction models has aided in calculating the risk of recurrent thrombotic events; however, there are several limitations with regards to routine use for all patients with acute VTE. More recently, focus has shifted towards the utility of novel biomarkers in the understanding of disease pathogenesis as well as their application in predicting recurrent VTE. Below, we review the current strategies used to predict the development of recurrent VTE, with emphasis on the application of several promising novel biomarkers in this field.

【 授权许可】

Unknown