Adjuvant Use of Melatonin with Fluoxetine for Management of Fibromyalgia

Medicine Science

Ihab Ibrahim Alkhalifa¹  Nizar Abdullateef Jassim²  Saad Abdulrahman Hussain³ 

[1] Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad;Department of Rheumatology, College of Medicine, University of Baghdad;College of Pharmacy, University of Baghdad;

关键词: Fibromyalgia;    Oxidative Stress;    Serotonin;    MDA;    Nitric oxide;   

DOI  :  10.5455/medscience.2012.01.8042

来源: DOAJ

【 摘 要 】

Fibromyalgia (FMS) is a chronic musculoskeletal disorder characterized by generalized muscular pain and tenderness at specific anatomical sites. Although melatonin was effective in treating the pain associated with this syndrome, no defined clinical evidence supports this claim. The present study was designed to evaluate the clinical significance of using melatonin, alone or in combination with fluoxetine in FMS. A double-blind clinical study was conducted on 45 patients with FMS randomized into 4 groups; group A, treated with fluoxetine 20mg/day alone; group B, treated with melatonin 5mg alone; group C, treated with combination of fluoxetine 20 mg+3 mg melatonin; group D treated with combination of fluoxetine 20 mg+5 mg melatonin. Both fluoxetine and melatonin were given once daily in the morning and night time respectively for 8 weeks. Each patient clinically evaluated using Fibromyalgia Impact Questionnaire (FIQ). Serum levels of serotonin, malondialehyde and nitric oxide were also evaluated. Using melatonin (3 and 5mg/day) in combination with 20mg/day fluoxetine significantly decreased total FIQ score values; the combination therapy significantly decreased serum serotonin level associated with reduction in the oxidative stress parameters (MDA and NO). In conclusion, adjuvant use of melatonin with fluoxetine improves the biochemical and clinical parameters of FMS patients. [Med-Science 2013; 2(1.000): 423-35]

【 授权许可】

Unknown