Impact of oligomerization on the allergenicity of allergens

Clinical and Molecular Allergy

Hossein Motedayyen¹  Amin Moradi Hasan-Abad¹  Reza Arefnezhad²  Mohsen Mehrabi³  Mohsen Mohammadi⁴  Hamed Mirzaei⁵ 

[1] Autoimmune Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences;Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences;Department of Medical Nanotechnology, School of Medicine, Shahroud University of Medical Sciences;Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences;

关键词: Oligomerization;    Allergenicity;    Protein-protein interactions;    Cross-linking;    High-affinity IgE receptor;   

DOI  :  10.1186/s12948-022-00172-1

来源: DOAJ

【 摘 要 】

Abstract Type I hypersensitivity (allergic reaction) is an unsuitable or overreactive immune response to an allergen due to cross-link immunoglobulin E (IgE) antibodies bound to its high-affinity IgE receptors (FcεRIs) on effector cells. It is needless to say that at least two epitopes on allergens are required to the successful and effective cross-linking. There are some reports pointing to small proteins with only one IgE epitope could cross-link FcεRI-bound IgE through homo-oligomerization which provides two same IgE epitopes. Therefore, oligomerization of allergens plays an indisputable role in the allergenic feature and stability of allergens. In this regard, we review the signaling capacity of the B cell receptor (BCR) complex and cross-linking of FcεRI which results in the synthesis of allergen-specific IgE. This review also discusses the protein-protein interactions involved in the oligomerization of allergens and provide some explanations about the oligomerization of some well-known allergens, such as calcium-binding allergens, Alt a 1, Bet v 1, Der p 1, Per a3, and Fel d 1, along with the effects of their concentrations on dimerization.

【 授权许可】

Unknown