Ischemic Stroke in a Patient with Stable CADASIL during COVID-19: A Case Report

Brain Sciences

Mariagrazia Rossi¹  Fioravante Capone¹  Alessandro Cruciani¹  Fabio Pilato¹  Vincenzo Di Lazzaro¹  Francesco Motolese¹ 

[1] Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy;

关键词: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL);    stroke;    hypercoagulability;    COVID-19;    SARS-CoV-2;    endothelial dysfunction;   

DOI  :  10.3390/brainsci11121615

来源: DOAJ

【 摘 要 】

Background: SARS-CoV-2 infection has been associated with different neurological conditions such as Guillain-Barré, encephalitis and stroke. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-vessel disease characterized by recurrent ischemic stroke, cognitive decline, migraine and mood disturbances. One of the mechanisms involved in CADASIL pathogenesis is endothelial dysfunction, which causes an increased risk of recurrent strokes. Since COVID-19 infection is also associated with coagulopathy and endothelial dysfunction, the risk of ischemic stroke might be even higher in this population. We describe the case of a CADASIL patient who developed an acute ischemic stroke after SARS-CoV-2 infection. In patients with diseases causing endothelial dysregulation, such as CADASIL, the hypercoagulability related to COVID-19 may contribute to the risk of stroke recurrence.

【 授权许可】

Unknown