A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides

International Journal of Molecular Sciences

Sudip Chakraborty¹  Naresh Kumar¹  Katrina Browne¹  Renxun Chen¹  DavidStClair Black¹  MarkD.P. Willcox²  WilliamR. Walsh³ 

[1] School of Chemistry, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia;School of Optometry and Vision Science, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia;Surgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, Prince of Wales Hospital, University of New South Wales (UNSW), Randwick NSW 2031, Australia;

关键词: antimicrobial peptides;    antibiotic-resistance;    antimicrobial activity;    peptide-based therapies;    cationic peptides;    clinical translation.;   

DOI  :  10.3390/ijms21197047

来源: DOAJ

【 摘 要 】

Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health. The traditional antibiotic pipeline has been exhausted, prompting research into alternate antimicrobial strategies. Inspired by nature, antimicrobial peptides are rapidly gaining attention for their clinical potential as they present distinct advantages over traditional antibiotics. Antimicrobial peptides are found in all forms of life and demonstrate a pivotal role in the innate immune system. Many antimicrobial peptides are evolutionarily conserved, with limited propensity for resistance. Additionally, chemical modifications to the peptide backbone can be used to improve biological activity and stability and reduce toxicity. This review details the therapeutic potential of peptide-based antimicrobials, as well as the challenges needed to overcome in order for clinical translation. We explore the proposed mechanisms of activity, design of synthetic biomimics, and how this novel class of antimicrobial compound may address the need for effective antibiotics. Finally, we discuss commercially available peptide-based antimicrobials and antimicrobial peptides in clinical trials.

【 授权许可】

Unknown