Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities

eLife

Linton R Harriss¹  Lex EX Leong²  Geraint B Rogers²  Robyn McDermott²  Jocelyn M Choo³  Steven L Taylor³  Steve L Wesselingh⁴  Sean M Taylor⁴  Kerry L Ivey⁴  Fredrick M Mobegi⁴  Fintan Thompson⁴ 

[1] Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Smithfield, Australia;SAHMRI Microbiome Research Laboratory, School of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, Australia;Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Smithfield, Australia;Microbiome and Host Health Programme, South Australian Health and Medical Research Institute, Adelaide, Australia;

关键词: indigenous health;    gut microbiome;    risk exposures;    cardiometabolic disease;    chronic inflammatory disease;    metagenomics;   

DOI  :  10.7554/eLife.58407

来源: DOAJ

【 摘 要 】

Poor diet and lifestyle exposures are implicated in substantial global increases in non-communicable disease burden in low-income, remote, and Indigenous communities. This observational study investigated the contribution of the fecal microbiome to influence host physiology in two Indigenous communities in the Torres Strait Islands: Mer, a remote island where a traditional diet predominates, and Waiben a more accessible island with greater access to takeaway food and alcohol. Counterintuitively, disease markers were more pronounced in Mer residents. However, island-specific differences in disease risk were explained, in part, by microbiome traits. The absence of Alistipes onderdonkii, for example, significantly (p=0.014) moderated island-specific patterns of systolic blood pressure in multivariate-adjusted models. We also report mediatory relationships between traits of the fecal metagenome, disease markers, and risk exposures. Understanding how intestinal microbiome traits influence response to disease risk exposures is critical for the development of strategies that mitigate the growing burden of cardiometabolic disease in these communities.

【 授权许可】

Unknown