Supramolecular Peptide Assemblies as Antimicrobial Scaffolds

Molecules

MatthewR. Aronson¹  ScottH. Medina¹  AndrewW. Simonson¹ 

[1] Department of Biomedical Engineering, The Pennsylvania State University, Suite 122, CBE Building, University Park, PA 16802-4400, USA;

关键词: self-assembly;    peptides;    antimicrobial;    multidrug resistance;    drug delivery;   

DOI  :  10.3390/molecules25122751

来源: DOAJ

【 摘 要 】

Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as attractive therapeutic platforms, operating as both the bactericidal agent and delivery vector for combinatorial antibiotics. Leveraging their programmable inter- and intra-molecular interactions, peptides can be engineered to form higher ordered monolithic or co-assembled structures, including nano-fibers, -nets, and -tubes, where their unique bifunctionalities often emerge from the supramolecular state. Further advancements have included the formation of macroscopic hydrogels that act as bioresponsive, bactericidal materials. This systematic review covers recent advances in the development of supramolecular antimicrobial peptide technologies and discusses their potential impact on future drug discovery efforts.

【 授权许可】

Unknown