Towards a Common Definition for the Diagnosis of Iron Deficiency in Chronic Inflammatory Diseases

Nutrients

Sigismond Lasocki¹  Hervé Puy²  Katell Peoc’h²  Valérie Andrieu³  Patrice Cacoub⁴  Jean-Noël Trochu⁵  Gabriel Choukroun⁶  Laurent Peyrin-Biroulet⁷  Elisabeth Luporsi⁸  Alain Cohen-Solal⁹ 

[1] Department of Anesthesia and Intensive Care Medicine, University Hospital of Angers, 49933 Angers, France;Department of Clinical Biochemistry, Beaujon Hospital, AP-HP, 92110 Clichy, France;Department of Hematology, Bichat-Claude Bernard Hospital, AP-HP, 75018 Paris, France;Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France;Institut du Thorax, INSERM, CNRS, University Hospital of Nantes, University of Nantes, 44093 Nantes, France;MP3CV Laboratory, EA7517, Jules Verne University of Picardie, 80054 Amiens, France;NGERE U1256, INSERM, Department of Gastroenterology, University Hospital of Nancy, University of Lorraine, 54500 Vandoeuvre-lès-Nancy, France;Oncology Unit, Mercy Hospital, 57530 Ars-Laquenexy, France;UMR-S 942 MASCOT, Paris University, Lariboisière Hospital, AP-HP, 75010 Paris, France;

关键词: iron deficiency;    ferritin;    TSAT;    chronic inflammatory disease;    definition;    epidemiology;   

DOI  :  10.3390/nu14051039

来源: DOAJ

【 摘 要 】

Iron deficiency (ID) in patients with chronic inflammatory diseases is frequent. However, under-diagnosis is also frequent due to the heterogeneity between guidelines from different medical societies. We applied a common definition for the diagnosis of ID to a large panel of patients with cancer, heart failure (HF), inflammatory bowel disease (IBD), and chronic kidney disease (CKD), where ID was defined as serum ferritin concentration <100 μg/L and/or a transferrin saturation (TSAT) index <20%. Prevalence estimates using this common definition were compared with that obtained with officially accepted definitions (ESMO 2018, ESC 2016, ECCO 2015, and ERBP 2013). For that purpose, we used data collected during the French CARENFER studies, which included 1232, 1733, 1090, and 1245 patients with cancer, HF, IBD, and CKD, respectively. When applying the common definition, ID prevalence increased to 58.1% (vs. 57.9%), 62.8% (49.6%), and 61.2% (23.7%) in cancer, HF, and IBD patients, respectively. Both prevalence estimates were similar (47.1%) in CKD patients. Based on our results, we recommend combining both ferritin concentration and TSAT index to define ID in patients with chronic inflammatory diseases. In those patients, adopting this common definition of ID should contribute to a better screening for ID, whatever the condition.

【 授权许可】

Unknown