Susceptibility of Broiler Chickens to Deoxynivalenol Exposure via Artificial or Natural Dietary Contamination

Animals

Miklós Mézes¹  MoniqueH. G. Tersteeg-Zijderveld²  Francesc Molist³  RegianeR. Santos³  Ronette Gehring⁴  MarjoleinA. M. Oosterveer-van der Doelen⁴ 

[1] Faculty of Agricultural and Environmental Sciences, Szent István University, 2100 Gödöllõ, Hungary;Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands;Schothorst Feed Research, 8200 AM Lelystad, The Netherlands;Veterinary Pharmacotherapy and Pharmacy, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104-106, 3584 CM Utrecht, The Netherlands;

关键词: mycotoxins;    fusarium;    poultry;    nutrient transporter;    intestinal morphology;   

DOI  :  10.3390/ani11040989

来源: DOAJ

【 摘 要 】

Multi-mycotoxin contamination of poultry diets is a recurrent problem, even if the mycotoxins levels are below EU recommendations. Deoxynivalenol (DON) is one of the main studied mycotoxins due to its risks to animal production and health. When evaluating the effects of DON, one must consider that under practical conditions diets will not be contaminated solely with this mycotoxin. In the present study, broiler chickens were fed diets with negligible mycotoxin levels or with naturally or artificially contaminated diets containing approximately 4000 μg/kg DON. Birds were sampled at D14 and D28. Naturally-contaminated diets caused the most harm to the birds, especially the young ones, which presented decreased jejunal villus height and increased lesions, down-regulation of a peptide transporter. At D28 broiler chickens seemed to have adapted to the dietary conditions, when no differences were observed in villus morphometry, together with up-regulation of a carbohydrate transporter. However, intestinal lesions remained present in these older birds.

【 授权许可】

Unknown