Ocular toxicity of tamoxifen

Indian Journal of Ophthalmology

关键词: Choroidal detachment - Secondary glaucoma - Superior ophthalmic vein - Thrombosis - Tamoxifen.;   

DOI  :  

来源: DOAJ

【 摘 要 】

Tamoxifen is an antioestrogen drug used widely in the management of oestrogen-dependant metastatic breast carcinoma. A number of ocular complications have been described secondary to tamoxifen therapy. We report two patients, one of whom had superior ophthalmic vein thrombosis and the other who had painful proptosis and acute angle-closure glaucoma with choroidal detachment secondary to tamoxifen therapy, both of which have not been reported earlier. In both patients the signs and symptoms resolved rapidly after the discontinuation of tamoxifen therapy. Awareness of the ocular toxicity of tamoxifen is essential as prompt withdrawal can result in resolution of most of the complications.

【 授权许可】

Unknown