Metabolic markers and oxidative stress in children’s obesity pathogenesis

Rossijskij Vestnik Perinatologii i Pediatrii

O. S. Medvedev¹  O. V. Povarova¹  E. I. Kalenikova¹  E. A. Gorodetskaya¹ 

[1] Lomonosov Moscow State University;

关键词: children, obesity, oxidative stress, q10 coenzyme, non-alcoholic fatty liver disease, insulin resistance, adipokines;   

DOI  :  10.21508/1027-4065-2020-65-1-22-29

来源: DOAJ

【 摘 要 】

The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction.

【 授权许可】

Unknown