A Density-Driven Method for the Placement of Biological Cells Over Two-Dimensional Manifolds

Frontiers in Neuroinformatics

Nicolas P. Rougier¹ 

[1] Inria Bordeaux - Sud-Ouest Research Centre, Talence, France;UMR5293 Institut des Maladies Neurodégénératives (IMN), Bordeaux, France;UMR5800 Laboratoire Bordelais de Recherche en Informatique (LaBRI), Talence, France;

关键词: stippling;    Voronoi;    spatial distribution;    density;    cells;    neurons;   

DOI  :  10.3389/fninf.2018.00012

来源: DOAJ

【 摘 要 】

We introduce a graphical method originating from the computer graphics domain that is used for the arbitrary placement of cells over a two-dimensional manifold. Using a bitmap image whose luminance provides cell density, this method guarantees a discrete distribution of the positions of the cells respecting the local density. This method scales to any number of cells, allows one to specify arbitrary enclosing shapes and provides a scalable and versatile alternative to the more classical assumption of a uniform spatial distribution. The method is illustrated on a discrete homogeneous neural field, on the distribution of cones and rods in the retina and on the neural density of a flattened piece of cortex.

【 授权许可】

Unknown