Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement

Journal of Clinical Medicine

Eduardo Tibiriçá¹  Vanessa Estato²  Marina Leardini-Tristao²  Emmanuel Andres³  Anne-Laure Charles⁴  Bernard Geny⁴  Anne Lejay⁴  Mégane Pizzimenti⁴  Alain Meyer⁴ 

[1] Instituto Nacional de Cardiologia, Ministério da Saúde, Rua das lanjeiras 374, 22240-006, Rio de Janeiro 22240-006, Brazil;Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, 21040-360, Rio de Janeiro, Brazil;Service de Médecine Interne, Diabète et Maladies Métaboliques, Pôle M.I.R.N.E.D., Hôpitaux Universitaires, CHRU Strasbourg, 67000 CEDEX, France;Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d’accueil 3072, 11 Rue Humann, 67000 Strasbourg, France;

关键词: peripheral arterial disease;    ankle-brachial index;    cognitive dysfunction;    brain;    exercise;    myokines;    microglia;    BDNF;    cathepsin-B;    irisin;   

DOI  :  10.3390/jcm8050653

来源: DOAJ

【 摘 要 】

Peripheral arterial disease (PAD), leading to intermittent claudication, critical ischemia with rest pain, and/or tissue damage, is a public health issue associated with significant morbidity and mortality. Little is known about the link between PAD, cognitive function, and whether exercise might reduce cognitive dysfunction in PAD patients, as previously observed concerning both quality of life and prognosis. This review highlights the fact that patients suffering from PAD often demonstrate cognitive dysfunction characterized by reduced performance in nonverbal reasoning, reduced verbal fluency, and decreased information processing speed and a greater risk for progression toward dementia. Further, the data presented support that physical exercise, likely through myokine secretion and microglial anti-inflammatory phenotype enhancement, might participate in the cognition protection in common clinical settings.

【 授权许可】

Unknown