Organoids to model the endometrium: implantation and beyond

Reproduction and Fertility

Komal Makwana¹  Emma S Lucas¹  Thomas M Rawlings¹  Maria Tryfonos¹ 

[1] Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK;

关键词: embryo implantation;    endometrium;    organoid;    assembloid;   

DOI  :  https://doi.org/10.1530/RAF-21-0023

来源: DOAJ

【 摘 要 】

Despite advances in assisted reproductive techniques in the 4 decades since the first human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation failure, and some will never achieve a successful pregnancy even in the absence of a confirmed dysfunction. Furthermore, 1–2% of couples who do conceive, either naturally or with assistance, will experience recurrent early loss of karyotypically normal pregnancies. In both cases, embryo-endometrial interaction is a clear candidate for exploration. The impossibility of studying implantation processes within the human body has necessitated the use of animal models and cell culture approaches. Recent advances in 3-dimensional modelling techniques, namely the advent of organoids, present an exciting opportunity to elucidate the unanswerable within human reproduction. In this review, we will explore the ontogeny of implantation modelling and propose a roadmap to application and discovery.

【 授权许可】

Unknown