Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms

Journal of Microbiology, Immunology and Infection

Ching-Lung Lo¹  Fu-Der Wang²  Ching-Hsun Wang³  Chien-Fang Tseng⁴  Pei-Ju Ting⁵  Po-Yen Liu⁶  Pi-Lien Hung⁷  Pei-Chin Lin⁸  Yi-Chin Chang⁹  Shih-Hao Lo^1,10  Ching-Hsiang Yang^1,11  Ing-Moi Hii^1,11  Yao-Shen Chen^1,12  Chen-Yen Kuo^1,12  Ling-Ju Huang^1,13  Tu-Hsuan Chang^1,14  Chun-Wen Cheng^1,15  Yu-Lung Hsu^1,16  Chia-Jung Chang^1,17  Yung-Ching Liu^1,18  Cheng Len Sy^1,18  Pao-Yu Chen^1,19  Susan Shin-Jung Lee^2,20  Hsiao-Wei Wang^2,21  Ya-Li Hu^2,22 

[1] Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;School of Medicine, National Yang Ming Chiao Tung University, Taiwan;Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan;Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan;Department of Pediatrics, Chang Gung Children's Hospital, College of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan;Department of Pediatrics, Chi-Mei Medical Center, Tainan, Taiwan;Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Department of Pediatrics, MacKay Children's Hospital and MacKay Memorial Hospital, Taipei, Taiwan;Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Division of General Medicine, Infectious Diseases, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;Division of Infectious Diseases, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan;Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan;

关键词: CRE;    CRAB;    VRE;    MDRO;    CRPA;    Guideline;   

DOI  :  

来源: DOAJ

【 摘 要 】

Antimicrobial drug resistance is one of the major threats to global health. It has made common infections increasingly difficult or impossible to treat, and leads to higher medical costs, prolonged hospital stays and increased mortality. Infection rates due to multidrug-resistant organisms (MDRO) are increasing globally. Active agents against MDRO are limited despite an increased in the availability of novel antibiotics in recent years. This guideline aims to assist clinicians in the management of infections due to MDRO. The 2019 Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group, comprising of infectious disease specialists from 14 medical centers in Taiwan, reviewed current evidences and drafted recommendations for the treatment of infections due to MDRO. A nationwide expert panel reviewed the recommendations during a consensus meeting in Aug 2020, and the guideline was endorsed by the Infectious Diseases Society of Taiwan (IDST). This guideline includes recommendations for selecting antimicrobial therapy for infections caused by carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa, carbapenem-resistant Enterobacterales, and vancomycin-resistant Enterococcus. The guideline takes into consideration the local epidemiology, and includes antimicrobial agents that may not yet be available in Taiwan. It is intended to serve as a clinical guide and not to supersede the clinical judgment of physicians in the management of individual patients.

【 授权许可】

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