Reference Intervals for Non-Fasting CVD Lipids and Inflammation Markers in Pregnant Indigenous Australian Women

Healthcare

Lyniece Keogh¹  Tracy L. Schumacher¹  Loretta Weatherall¹  Kym M. Rae¹  Kirsty G. Pringle¹  Don Clausen²  Christopher Oldmeadow³ 

[1] Gomeroi gaaynggal Centre, Faculty of Health and Medicine, University of Newcastle, Tamworth, NSW 2340, Australia;New South Wales Health Pathology, Tamworth, NSW 2340, Australia;School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia;

关键词: cardiovascular;    biomarkers;    lipids;    inflammation;    pregnancy;    gestation;    Australian Aborigine;    reference growth curves;   

DOI  :  10.3390/healthcare5040072

来源: DOAJ

【 摘 要 】

Indigenous Australians experience high rates of cardiovascular disease (CVD). The origins of CVD may commence during pregnancy, yet few serum reference values for CVD biomarkers exist specific to the pregnancy period. The Gomeroi gaaynggal research project is a program that undertakes research and provides some health services to pregnant Indigenous women. Three hundred and ninety-nine non-fasting samples provided by the study participants (206 pregnancies and 175 women) have been used to construct reference intervals for CVD biomarkers during this critical time. A pragmatic design was used, in that women were not excluded for the presence of chronic or acute health states. Percentile bands for non-linear relationships were constructed according to the methods of Wright and Royston (2008), using the xriml package in StataIC 13.1. Serum cholesterol, triglycerides, cystatin-C and alkaline phosphatase increased as gestational age progressed, with little change seen in high-sensitivity C-Reactive Protein and γ glutamyl transferase. Values provided in the reference intervals are consistent with findings from other research projects. These reference intervals will form a basis with which future CVD biomarkers for pregnant Indigenous Australian women can be compared.

【 授权许可】

Unknown