Clinical‐radiological characteristics and intestinal microbiota in patients with pancreatic immune‐related adverse events

Thoracic Cancer

Jia‐ming Qian¹  Bei Tan¹  Yue Li¹  Qi Guo²  Hao Tang³  Liang Zhu⁴  Meng‐zhao Wang⁵  Min‐jiang Chen⁵  Yan Xu⁵  Xin‐miao Jia⁶ 

[1] Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China;Department of Gynecology & Obstetrics Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China;Department of Internal Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China;Department of Radiology Chinese Academy of Medical Science & Peking Union Medical College Beijing China;Department of Respiratory and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China;Medical Research Center Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China;

关键词: immune checkpoint inhibitors;    immune‐related adverse events;    microbiota;    pancreatic disease;   

DOI  :  10.1111/1759-7714.13990

来源: DOAJ

【 摘 要 】

Abstract Background The pancreatic immune‐related adverse event (irAE) is a rare but increasingly occurrence disease with limited knowledge, which was associated with the use of immune checkpoint inhibitors (ICIs). Methods In this case series study of pancreatic irAE patients, clinical and radiological manifestations are summarized. Baseline and post‐treatment fecal microbiota of immune‐related acute pancreatitis (irAP) patients were analyzed by the 16 s rDNA amplicon sequencing method. Results A total of six patients were enrolled into the study, and the onset of pancreatic irAEs occurred a median of 105 days after a median of 4.5 cycles with immune checkpoint inhibitors (ICIs). All patients had an effective response to ICIs. Abdominal pain was the main clinical manifestation. Serum amylase (sAMY) and lipase (sLIP) had dynamic changes parallel to clinical severity. Contrast‐enhanced computed tomography (CT) did not accurately reveal the level of inflammation. However, magnetic resonance imaging (MRI) was a sensitive imaging method which showed decreased and increased signal intensity of pancreatic parenchyma in T1‐weighted fat‐saturated and diffusion‐weighted imaging, respectively. Glucocorticoids were the main treatment with a rapid initial effect followed by a slow improvement. After reinitiation of ICI therapy, pancreatic irAEs either deteriorated, remained stable or the patient developed severe pancreatic β‐cell destruction without irAP recurrence. The baseline microbiota of irAP had low Bacteroidetes/Firmicutes ratio at phylum level, low relative abundance of Alistipes, Bacteroides and high Lachnospiraceae at genus level, compared to levels of pancreatic β‐cell destruction and post‐treatment of irAP. Conclusions Pancreatic irAE patients had corresponding abdominal pain and increase in sAMY/sLIP. MRI was found to be an ideal imaging modality. Treatment with glucocorticoids were the main approach. The microbiota showed relative changes at baseline and during treatment.

【 授权许可】

Unknown