Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy

Frontiers in Cellular Neuroscience

Stefania Zappettini¹  Antoine Ghestem¹  Monique Esclapez¹  Christophe Bernard¹  Luc Buée²  Sébastien Carrier²  Emilie Faivre²  David Blum² 

[1] Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France;Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, Lille, France;

关键词: caffeine;    development;    Alzheimer;    tauopathy;    hippocampus;    memory;   

DOI  :  10.3389/fncel.2019.00438

来源: DOAJ

【 摘 要 】

Psychoactive drugs used during pregnancy can affect the development of the brain of offspring, directly triggering neurological disorders or increasing the risk for their occurrence. Caffeine is the most widely consumed psychoactive drug, including during pregnancy. In Wild type mice, early life exposure to caffeine renders offspring more susceptible to seizures. Here, we tested the long-term consequences of early life exposure to caffeine in THY-Tau22 transgenic mice, a model of Alzheimer’s disease-like Tau pathology. Caffeine exposed mutant offspring developed cognitive earlier than water treated mutants. Electrophysiological recordings of hippocampal CA1 pyramidal cells in vitro revealed that early life exposure to caffeine changed the way the glutamatergic and GABAergic drives were modified by the Tau pathology. We conclude that early-life exposure to caffeine affects the Tau phenotype and we suggest that caffeine exposure during pregnancy may constitute a risk-factor for early onset of Alzheimer’s disease-like pathology.

【 授权许可】

Unknown