Hemato | |
Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes | |
Kristin H. Karner1  Madhu P. Menon1  Karthik A. Ganapathi2  | |
[1] ARUP Laboratories and Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA;Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA; | |
关键词: T follicular helper cells; TFH lymphoma; angioimmunoblastic T-cell lymphoma; follicular T-cell lymphoma; peripheral T-cell lymphoma of T-follicular helper immunophenotype; peripheral T-cell lymphoma; | |
DOI : 10.3390/hemato3010020 | |
来源: DOAJ |
【 摘 要 】
Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features. Angioimmunoblastic T-cell lymphoma (AITL) is the prototypical TFH lymphoma; in addition, the 2017 revised World Health Organization (WHO) 4th edition recognizes two other unique subtypes: follicular T-cell lymphoma (FTCL) and nodal peripheral T-cell lymphoma with the T follicular helper phenotype (PTCL-TFH). This review discusses the morphologic spectrum, immunophenotype, diagnostic mimics/pitfalls, and unique genetic attributes of this category of T-cell lymphomas.
【 授权许可】
Unknown