Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes

Hemato

Kristin H. Karner¹  Madhu P. Menon¹  Karthik A. Ganapathi² 

[1] ARUP Laboratories and Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA;Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA;

关键词: T follicular helper cells;    TFH lymphoma;    angioimmunoblastic T-cell lymphoma;    follicular T-cell lymphoma;    peripheral T-cell lymphoma of T-follicular helper immunophenotype;    peripheral T-cell lymphoma;   

DOI  :  10.3390/hemato3010020

来源: DOAJ

【 摘 要 】

Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features. Angioimmunoblastic T-cell lymphoma (AITL) is the prototypical TFH lymphoma; in addition, the 2017 revised World Health Organization (WHO) 4th edition recognizes two other unique subtypes: follicular T-cell lymphoma (FTCL) and nodal peripheral T-cell lymphoma with the T follicular helper phenotype (PTCL-TFH). This review discusses the morphologic spectrum, immunophenotype, diagnostic mimics/pitfalls, and unique genetic attributes of this category of T-cell lymphomas.

【 授权许可】

Unknown