Adiponectin Gene Polymorphism (rs17300539) Has No Influence on the Occurrence of Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Genes

Sylwester Ciećwież¹  Izabela Nowak¹  Agnieszka Brodowska¹  Beata Łój²  Jacek Brodowski³ 

[1] Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, 71-256 Szczecin, Poland;Klinik für Gynäkologie und Geburtshilfe, das Lehrkrankenhaus Sana Hanse Klinikum Wismar, Universität Rostock, 23966 Wismar, Germany;Primary Healthcare Center, Pomeranian Medical University, 71-210 Szczecin, Poland;

关键词: adiponectin;    polycystic ovaries;    metabolic syndrome;    genetic testing;    genetic predisposition;    screening;   

DOI  :  10.3390/genes12121902

来源: DOAJ

【 摘 要 】

Adiponectin (rs17300539) is implicated in the pathogenesis of metabolic syndrome (MS), a common comorbidity of polycystic ovarian syndrome (PCOS). The aim of this study was to analyze the association between adiponectin gene polymorphism and incidence of MS in patients with PCOS. The study included 201 women (age 18 to 35 years), among them 81 patients with PCOS without concomitant MS, 70 subjects with PCOS and concomitant, and 50 regularly menstruating controls. Adiponectin gene polymorphism (11391 G/A, rs17300539) was determined by means of a real-time PCR. The study groups did not differ significantly in terms of their age and frequencies of various genotypes of the adiponectin gene polymorphism. The largest proportion in the whole group was Caucasian women (n = 178, 88.56%), who carried the GG genotype of the polymorphism; frequencies of GA and AA genotypes in the whole study group were 10.94% (n = 22) and 0.5% (n = 1), respectively. The presence of G or A allele of the rs17300539 adiponectin gene polymorphism was not associated with a greater likelihood of PCOS with/without concomitant MS. The hereby presented findings imply that MS is a common comorbidity in women with PCOS. However, the incidence of concomitant MS does not seem to be associated with adiponectin gene polymorphism.

【 授权许可】

Unknown