Effect of maternal vitamin D supplementation on nasal pneumococcal acquisition, carriage dynamics and carriage density in infants in Dhaka, Bangladesh

BMC Infectious Diseases

Lisa G. Pell¹  Eric O. Ohuma¹  Shaun K. Morris¹  Eleanor M. Pullangyeum¹  Davidson H. Hamer²  Daniel E. Roth³  Stanley H. Zlotkin³  Mahgol Taghivand³  Jonathan B. Gubbay⁴  Mohammed Z. Rahman⁵  Tahmeed Ahmed⁵  Abdullah A. Mahmud⁵ 

[1] Centre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children;Department of Global Health, Boston University School of Public Health;Department of Nutritional Sciences, University of Toronto;Department of Pediatrics, Hospital for Sick Children & University of Toronto;Infections Diseases Division & Nutrition and Clinical Services Division, icddr,b;

关键词: Pneumococcal carriage;    Vitamin D;    Maternal supplementation;    Infants;    Bangladesh;   

DOI  :  10.1186/s12879-022-07032-y

来源: DOAJ

【 摘 要 】

Abstract Background Invasive pneumococcal disease is a major cause of infant morbidity and death worldwide. Vitamin D promotes anti-pneumococcal immune responses in vitro, but whether improvements in infant vitamin D status modify risks of nasal pneumococcal acquisition in early life is not known. Methods This is a secondary analysis of data collected in a trial cohort in Dhaka, Bangladesh. Acute respiratory infection (ARI) surveillance was conducted from 0 to 6 months of age among 1060 infants of women randomized to one of four pre/post-partum vitamin D dose combinations or placebo. Nasal swab samples were collected based on standardized ARI criteria, and pneumococcal DNA quantified by qPCR. Hazards ratios of pneumococcal acquisition and carriage dynamics were estimated using interval-censored survival and multi-state modelling. Results Pneumococcal carriage was detected at least once in 90% of infants by 6 months of age; overall, 69% of swabs were positive (2616/3792). There were no differences between any vitamin D group and placebo in the hazards of pneumococcal acquisition, carriage dynamics, or carriage density (p > 0.05 for all comparisons). Conclusion Despite in vitro data suggesting that vitamin D promoted immune responses against pneumococcus, improvements in postnatal vitamin D status did not reduce the rate, alter age of onset, or change dynamics of nasal pneumococcal colonization in early infancy. Trial registration Registered in ClinicalTrials.gov with the registration number of NCT02388516 and first posted on March 17, 2015.

【 授权许可】

Unknown