Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults

Frontiers in Aging Neuroscience

Arvid eLundervold¹  Astri Johansen Lundervold²  Erlend eHodneland³  Judit eHaász³  Alexandra eVik³  Martin eYstad³ 

[1] Haukeland University Hospital;Kavli Research center of aging and dementia , Haraldsplass Deaconess Hospital;University of Bergen;

关键词: tractography;    Diffusion Weighted Imaging;    fractional anisotropy;    healthy aging;    longitudinal study;    3D MRI;   

DOI  :  10.3389/fnagi.2015.00081

来源: DOAJ

【 摘 要 】

Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.

【 授权许可】

Unknown