Pluripotent Cell Models for Gonadal Research

International Journal of Molecular Sciences

Anna Biason-Lauber¹  Daniel Rodríguez Gutiérrez¹ 

[1] Endocrinology Division, Department of Endocrinology, Metabolism and Cardiovascular System, Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland;

关键词: induced pluripotent stem cells;    ipscs;    dsd;    cell model;    sertoli cell;    granulosa cells;    germ cells;    cellular reprogramming;    patient-specific model;   

DOI  :  10.3390/ijms20215495

来源: DOAJ

【 摘 要 】

Sex development is a complex process involving many genes and hormones. Defects in this process lead to Differences of Sex Development (DSD), a group of heterogeneous conditions not as rare as previously thought. Part of the obstacles in proper management of these patients is due to an incomplete understanding of the genetics programs and molecular pathways involved in sex development and DSD. Several challenges delay progress and the lack of a proper model system for the single patient severely hinders advances in understanding these diseases. The revolutionary techniques of cellular reprogramming and guided in vitro differentiation allow us now to exploit the versatility of induced pluripotent stem cells to create alternatives models for DSD, ideally on a patient-specific personalized basis.

【 授权许可】

Unknown