Towards a molecular classification of colorectal cancer:The role of microsatellite instability status

Frontiers in Oncology

Karl eHeinimann¹ 

[1] Medical Genetics, Dept. of Biomedicine, University Hospital Basel;

关键词: therapy;    colorectal cancer (CRC);    mismatch repair (MMR);    microsatellite instability (MSI);    Lynch syndrome (LS);    hereditary non-polyposis colon cancer (HNPCC);   

DOI  :  10.3389/fonc.2013.00272

来源: DOAJ

【 摘 要 】

Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair (MMR) deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This short review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today’s clinical practice.

【 授权许可】

Unknown