Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC

Cancers

Isabel Vilaseca¹  Paloma Bragado²  Carla Meler-Claramonte³  Mercedes Camacho⁴  Francesc Xavier Avilés-Jurado⁵  Ximena Terra⁶  Xavier León Vintró⁷  Gemma Fuster⁸ 

[1] Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, 2017-SGR-01581, 08001 Barcelona, Spain;Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain;Doctoral Programme in Biomedicine, Universitat Rovira i Virgili, 43002 Tarragona, Spain;Genomics of Complex Diseases, Research Institute Hospital Sant Pau, IIB Sant Pau, 08041 Barcelona, Spain;IISPV, Institut d’Investigació Sanitària Pere Virgili, 43002 Tarragona, Spain;MoBioFood Research Group, Biochemistry and Biotechnology Department, Universitat Rovira i Virgili, 43002 Tarragona, Spain;Otorhinolaryngology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain;Tissue Repair and Regeneration Laboratory, Department of Biosciences, Faculty of Sciences and Technology, University of Vic, 08500 Vic, Spain;

关键词: semaphorin-3F;    neuropilin-2;    occult lymph node metastases;    elective neck dissection;    head and neck squamous cell carcinoma;    HNSCC;   

DOI  :  10.3390/cancers14092259

来源: DOAJ

【 摘 要 】

The expression of the semaphorin-3F (SEMA3F) and neuropilin-2 (NRP2) is involved in the regulation of lymphangiogenesis. The present study analyzes the relationship between the transcriptional expression of the SEMA3F-NRP2 genes and the presence of occult lymph node metastases in patients with cN0 head and neck squamous cell carcinomas. We analyzed the transcriptional expression of SEMA3F and NRP2 in a cohort of 53 patients with cN0 squamous cell carcinoma treated with an elective neck dissection. Occult lymph node metastases were found in 37.7% of the patients. Patients with occult lymph node metastases (cN0/pN+) had significantly lower SEMA3F expression values than patients without lymph node involvement (cN0/pN0). Considering the expression of the SEMA3F-NRP2 genes, patients were classified into two groups according to the risk of occult nodal metastasis: Group 1 (n = 34), high SEMA3F/low NRP2 expression, with a low risk of occult nodal involvement (14.7% cN0/pN+); Group 2 (n = 19), low SEMA3F or high SEMA3F/high NRP2 expression, with a high risk of occult nodal involvement (78.9% cN0/pN+). Multivariate analysis showed that patients in Group 2 had a 26.2 higher risk of lymph node involvement than patients in Group 1. There was a significant relationship between the transcriptional expression values of the SEMA3F-NRP2 genes and the risk of occult nodal metastases.

【 授权许可】

Unknown