Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study

BMC Medicine

Maria Santucci de Magistris¹  Elena Molina-Portillo²  José María Huerta²  Timothy J. Key³  Rosario Tumino⁴  Domenico Palli⁵  Anne Tjonneland⁶  Anja Olsen⁶  Jules Griffin⁷  Kim Overvad⁸  Pia T. Dinesen⁸  Fulvio Ricceri⁹  Heiner Boeing^1,10  Matthias B. Schulze^1,11  Janine Kröger^1,11  Kay-Tee Khaw^1,12  Giovanna Tagliabue^1,13  Tilman Kühn^1,14  Verena Andrea Katzke^1,14  Francesca Romana Mancini^1,15  Guy Fagherazzi^1,15  Courtney Dow^1,15  Nadia Slimani^1,16  Paul W. Franks^1,17  Peter M. Nilsson^1,17  Albert Koulman^1,18  Fumiaki Imamura^1,19  Nita G. Forouhi^1,19  Zheng Ye^1,19  Stephen J. Sharp^1,19  Ju-Sheng Zheng^1,19  Claudia Langenberg^1,19  Nicholas J. Wareham^1,19  Annemieke M. W. Spijkerman^2,20  Sandra Colorado-Yohar^2,21  Aurelio Barricarte^2,22  Marcela Guevara^2,22  Jose Ramón Quirós^2,23  Miren Dorronsoro^2,24  Elio Riboli^2,25  Olov Rolandsson^2,26  Antonio Agudo^2,27  Ivonne Sluijs^2,28  Yvonne T. van der Schouw^2,28  Edith J. M. Feskens^2,29 

[1] A.O.U. Federico II;CIBER Epidemiology and Public Health (CIBERESP);Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford;Cancer Registry and Histopathology Department, “Civic M.P. Arezzo” Hospital, ASP;Cancer Research and Prevention Institute (ISPO);Danish Cancer Society Research Center;Department of Biochemistry, University of Cambridge;Department of Cardiology, Aalborg University Hospital;Department of Clinical and Biological Sciences, University of Turin;Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke;Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke;Department of Public Health and Primary Care, University of Cambridge;Fondazione IRCCS Istituto Nazionale dei Tumori;German Cancer Research Center (DKFZ), Division of Cancer Epidemiology;INSERM U1018, Center for Research in Epidemiology and Population Health;International Agency for Research on Cancer;Lund University;MRC Elsie Widdowson Laboratory;MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine;National Institute for Public Health and the Environment (RIVM);Navarra Institute for Health Research (ldiSNA);Navarra Public Health Institute (ISPN);Public Health Directorate;Public Health Division of Gipuzkoa;School of Public Health, Imperial College London;Umeå University;Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat;University Medical Center Utrecht;Wageningen University;

关键词: Saturated fatty acids;    Odd-chain;    Even-chain;    Very-long-chain;    Metabolic markers;    Lipids;   

DOI  :  10.1186/s12916-017-0968-4

来源: DOAJ

【 摘 要 】

Abstract Background Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.

【 授权许可】

Unknown