Role of microRNAs in the Regulation of alpha-Synuclein Expression: a Systematic Review

Frontiers in Molecular Neuroscience

Ariadna Recasens²  Carolyn M Sue²  Celine Perier³ 

[1] The Royal North Shore Hospital, Northern Sydney Local Health District;University of Sydney, Sydney;Vall d’Hebron Research Institute and Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED);

关键词: alpha-Synuclein;    Gene Expression;    microRNA;    miRNA;    Parkinson’s disease;    α-Synuclein;   

DOI  :  10.3389/fnmol.2016.00128

来源: DOAJ

【 摘 要 】

Growing evidence suggests that increased levels of α-synuclein might contribute to the pathogenesis of Parkinson’s disease (PD) and therefore, it is crucial to understand the mechanisms underlying α-synuclein expression. Recently, microRNAs (miRNAs) have emerged as key regulators of gene expression involved in several diseases such as PD and other neurodegenerative disorders. A systematic literature search was performed here to identify microRNAs that directly or indirectly impact in α-synuclein expression/accumulation and describe its mechanism of action. A total of 27 studies were incorporated in the review showing evidences that 6 microRNAs directly bind and regulate α-synuclein expression while several miRNAs impact on α-synuclein expression indirectly by targeting other genes. In turn, α-synuclein overexpression also impacts miRNAs expression, indicating the complex network between miRNAs and α-synuclein. From the current knowledge on the central role of α-synuclein in PD pathogenesis/progression, miRNAs are likely to play a crucial role at different stages of PD and might potentially be considered as new PD therapeutic approaches.

【 授权许可】

Unknown