Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis

JACC: Basic to Translational Science

Dan Rafiroiu, PhD¹  Julian P. Gunn, MD²  Patricia V. Lawford, PhD²  Angela Lungu, PhD²  Jeroen F.A. Feher, MSc²  Susheel Varma, PhD²  Paul D. Morris, PhD²  Daniel Alejandro Silva Soto, PhD²  D. Rodney Hose, PhD² 

[1] Department of Electrotechnics and Electrical Measurements, Technical University of Cluj-Napoca, Cluj-Napoca, Romania;Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;

关键词: computational fluid dynamics;    coronary artery disease;    coronary microvascular physiology;    coronary modelling;    coronary physiology;    fractional flow reserve;    virtual fractional flow reserve;   

DOI  :  10.1016/j.jacbts.2017.04.003

来源: DOAJ

【 摘 要 】

Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel “pseudotransient” analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This protocol generates vFFR results in 189 s (cf >24 h for transient analysis) using a desktop PC, with <1% error relative to that of full-transient computational fluid dynamics analysis. Sensitivity analysis demonstrated that physiological lesion significance was influenced less by coronary or lesion anatomy (33%) and more by microvascular physiology (59%). If coronary microvascular resistance can be estimated, vFFR can be accurately computed in less time than it takes to make invasive measurements.

【 授权许可】

Unknown