Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vaginosis?

Antibiotics

Bey-Hing Goh¹  Valliammai Jayanthi Thirunavuk Arasoo²  Kok-Gan Chan³  Hooi-Leng Ser⁴  Loh Teng-Hern Tan⁴  Rebecca Jane Joseph⁴  Yi-He Kuai⁴  Priyia Pusparajah⁴  Nurul-Syakima Ab Mutalib⁴  Learn-Han Lee⁴  Vengadesh Letchumanan⁴  Lijing Wang⁵ 

[1] Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia;Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Johor Bahru 80100, Malaysia;Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia;Novel Bacteria and Drug Discovery Research Group (NBDD), Microbes and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia;Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China;

关键词: bacterial vaginosis;    microbiome;    probiotics;    Lactobacillus;    Gardnerella;    VMT;   

DOI  :  10.3390/antibiotics10060719

来源: DOAJ

【 摘 要 】

Bacterial vaginosis (BV) has been reported in one-third of women worldwide at different life stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common cause of abnormal vaginal discharge and is associated with other health issues. Since the first description of anaerobic microbes associated with BV like Gardnerella vaginalis in the 1950s, researchers have stepped up the game by incorporating advanced molecular tools to monitor and evaluate the extent of dysbiosis within the vaginal microbiome, particularly on how specific microbial population changes compared to a healthy state. Moreover, treatment failure and BV recurrence rate remain high despite the standard antibiotic treatment. Consequently, researchers have been probing into alternative or adjunct treatments, including probiotics or even vaginal microbiota transplants, to ensure successful treatment outcomes and reduce the colonization by pathogenic microbes of the female reproductive tract. The current review summarizes the latest findings in probiotics use for BV and explores the potential of vaginal microbiota transplants in restoring vaginal health.

【 授权许可】

Unknown