Mammary adenocarcinoma with widespread metastasis in a lion (Panthera leo)

Macedonian Veterinary Review

Trpe Ristoski¹  Ivica Gjurovski¹  Monika Dovenska¹  Slavica Kostadinova Kunovska²  Vesna Levajkovic Trajkov³  Jordanco Milosevski³ 

[1] Faculty of Veterinary Medicine, University “Ss Cyril and Methodius”, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of North Macedonia;Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of North Macedonia;Zoo Garden Skopje, Republic of North Macedonia;

关键词: carcinoma;    mammary gland;    lion;   

DOI  :  10.2478/macvetrev-2019-0019

来源: DOAJ

【 摘 要 】

A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.

【 授权许可】

Unknown