Microbiome Resilience and Health Implications for People in Half-Year Travel

Frontiers in Immunology

Jianjun Peng¹  Feng Guan¹  Zhiqiang Hu¹  Yang Xia¹  Liqun Chu¹  Quan Zhou¹  Rui Wang¹  Hong Liu¹  Jing Wu¹  Feng Chen¹  Yawen Liu¹  Hong Peng¹  Hongxing Song¹  Shuai Cheng Li²  Pengshuo Yang⁴  Mingyue Cheng⁴  Kang Ning⁴  Maozhen Han⁴  Guangming Tan⁵  Dongbo Bu⁵  Shiwei Sun⁵ 

[1] Beijing Shijitan Hospital, Capital Medical University, Beijing, China;Department of Computer Science, City University of Hong Kong, Hong Kong, Hong Kong SAR, China;Key Lab of Intelligent Information Processing, State Lab of Computer Architecture, Institute of Computing Technology, Chinese Academy of Sciences,Beijing, China;Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China;School of Computer and Control, University of Chinese Academy of Sciences, Beijing, China;

关键词: travel;    enterotype;    microbiome;    bi-directional plasticity;    resilience;    dietary shift;   

DOI  :  10.3389/fimmu.2022.848994

来源: DOAJ

【 摘 要 】

Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT’s gut microbial compositions gradually transformed to the local TAT’s enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT’s return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT’ returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people’s dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health.

【 授权许可】

Unknown