The Effect of Blood Loss in the Presence and Absence of Severe Soft TissueInjury on Hemodynamic and Metabolic Parameters; an Experimental study

Emergency

Seyed Mostafa Sheid Moosavi¹  Farzaneh Ketabchi¹  Hamid Reza Abassi¹  Ali Mohammad Moradi²  Omid Aj²  Aryan Dokht Tamadon³  Davood Mehrabani³  Shahram Paydar⁴  Shahram Bolandparvaz⁴ 

[1] Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Shock, hemorrhagic;    soft tissue injuries;    hemodynamics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. Methods: Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft tissue injury groups. The changes in blood pressure, central venous pressure (CVP) level, acidity (pH), and base excess were dynamically monitored and comparedsented. Results: Mean arterial blood pressure decreased significantly in hemorrhagic shock (df: 12; F=10.9; p<0.001) and severe soft tissue injury + hemorrhagic shock (df: 12; F=11.7; p<0.001) groups 15 minutes and 5 minutes after injury, respectively. A similar trend was observed in CVP in severe soft tissue injury + hemorrhagic shock group (df: 12; F=8.9; p<0.001). After 40 minutes, pH was significantly lower in hemorrhagic shock (df: 12; F=6.8; p=0.009) and severe soft tissue injury + hemorrhagic shock (df: 12; F=7.9; p=0.003) groups. Base excess changes during follow ups have a similar trend. (df: 12; F=11.3; p<0.001). Conclusion: The results of this study have shown that the effect of hemorrhage on the decrease of mean arterial blood pressure, CVP, pH, and base excess is the same in the presence or absence of soft tissue injury.

【 授权许可】

Unknown