Cost-effectiveness of TAS-102 plus bevacizumab versus TAS-102 monotherapy in patients with metastatic colorectal cancer

BMC Gastroenterology

Yasuhiro Ito¹  Takayuki Takahashi¹  Norihiro Kishida¹  Kiyoaki Sugiura¹  Yusuke Nishi¹  Yuki Seo¹  Hideyuki Tokura¹  Yoshihiko Onishi¹  Hikaru Aoki¹  Motomu Tanaka¹ 

[1] Ashikaga Red Cross Hospital;

关键词: Colorectal cancer;    TAS-102;    Bevacizumab;    Cost-effectiveness;   

DOI  :  10.1186/s12876-021-01771-z

来源: DOAJ

【 摘 要 】

Abstract Background TAS-102 plus bevacizumab is an anticipated combination regimen for patients who have metastatic colorectal cancer. However, evidence supporting its use for this indication is limited. We compared the cost-effectiveness of TAS-102 plus bevacizumab combination therapy with TAS-102 monotherapy for patients with chemorefractory metastatic colorectal cancer. Method Markov decision modeling using treatment costs, disease-free survival, and overall survival was performed to examine the cost-effectiveness of TAS-102 plus bevacizumab combination therapy and TAS-102 monotherapy. The Japanese health care payer’s perspective was adopted. The outcomes were modeled on the basis of published literature. The incremental cost-effectiveness ratio (ICER) between the two treatment regimens was the primary outcome. Sensitivity analysis was performed and the effect of uncertainty on the model parameters were investigated. Results TAS-102 plus bevacizumab had an ICER of $21,534 per quality-adjusted life-year (QALY) gained compared with TAS-102 monotherapy. Sensitivity analysis demonstrated that TAS-102 monotherapy was more cost-effective than TAS-102 and bevacizumab combination therapy at a willingness-to-pay of under $50,000 per QALY gained. Conclusions TAS-102 and bevacizumab combination therapy is a cost-effective option for patients who have metastatic colorectal cancer in the Japanese health care system.

【 授权许可】

Unknown