Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee

Applied Sciences

Jerome Hollenstein¹  Grahame Busby¹  Gábor Vásárhelyi²  László Hangody²  Agnes Berta²  AndrewK. Lynn³  Alan Getgood⁴  MatthewS. Shive⁵  Imre Kéki⁶  Saara Totterman⁷ 

[1]Collagen Solutions Plc Eden Prairie, Eden Prairie, MN 55344, USA

[2]Department of Orthopaedics and Traumatology, Uzsoki Hospital, 1145 Budapest, Hungary

[3]Fluid Analytics Cambridge, Cambridge CB1 8DH, UK

[4]Fowler Kennedy Sport Medicine Clinic, University of Western Ontario, London, ON N6A 3K7, Canada

[5]MS2 INSIGHT Consulting, LLC, Denver, CO 80220, USA

[6]Nuclear Medicine Uzsoki Hospital, 1145 Budapest, Hungary

[7]Qmetrics Technologies Pittsford, New York, NY 14534, USA

关键词: biphasic scaffold;    osteochondral defect;    cartilage repair;    quantitative MRI;    calcium phosphate;   

DOI  :  10.3390/app10165642

来源: DOAJ

【 摘 要 】

Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free biphasic scaffold. Structural outcomes were assessed using quantitative 3-D magnetic resonance imaging (MRI) and morphological segmentation to determine the percentage of defect filling and repair cartilage T2 relaxation times, and clinical outcomes were determined with the modified Cincinnati Rating System, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Seventeen subjects with osteochondral defects in the knee were treated with ChondroMimetic scaffolds, from which 15 returned for long-term evaluation at a mean follow-up of 7.9 ± 0.3 years. The defects treated were trochlear donor sites for mosaicplasty in 13 subjects, and medial femoral condyle defects in 2 subjects. MRI analysis of scaffold-treated defects found a mean total defect filling of 95.2 ± 3.6%, and a tissue mean T2 relaxation time of 52.5 ± 4.8 ms, which was identical to the T2 of ipsilateral control cartilage (52.3 ± 9.2 ms). The overall modified Cincinnati Rating System score was statistically significant from baseline (p = 0.0065), and KOOS subscales were equivalent to other cartilage repair techniques. ChondroMimetic treatment resulted in a consistently high degree of osteochondral defect filling with durable, cartilage-like repair tissue at 7.9 years, potentially associated with clinical improvement.

【 授权许可】

Unknown