The Global Prevalence of Daptomycin, Tigecycline, and Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Strains From Human Clinical Samples: A Systematic Review and Meta-Analysis

Frontiers in Medicine

Alex van Belkum¹  Parastoo Sharifian²  Nazila Bostanshirin²  Narjess Bostanghadiri³  Davood Darban-Sarokhalil³  Bahareh Hajikhani⁴  Nafiseh Khosravi-Dehaghi⁶  Masoud Dadashi⁷ 

[1] Data Analytics Unit, bioMérieux, La Balme-les-Grottes, France;Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Pharmacognosy, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran;Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;

关键词: E. faecalis;    E. faecium;    tigecyclin;    daptomycin;    linezolid;    resistant;   

DOI  :  10.3389/fmed.2021.720647

来源: DOAJ

【 摘 要 】

Background and Aim: The predominant species of the Enterococcus, Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) cause great variety of infections. Therefore, the expansion of antimicrobial resistance in the Enterococcus is one of the most important global concerns. This study was conducted to investigate the prevalence of resistance to linezolid, tigecycline, and daptomycin among enterococcal strains isolated from human clinical specimens worldwide.Methods: Several databases including Web of Science, EMBASE, and Medline (via PubMed), were carefully searched and reviewed for original research articles available in databases and published between 2000 and 2020. A total of 114 studies worldwide that address E. faecalis and E. faecium resistance to linezolid, tigecycline, and daptomycin were analyzed by STATA software.Results: The overall prevalence of antibiotic-resistant E. faecalis and E. faecium was reported to be 0.9 and 0.6%, respectively. E. faecalis and E. faecium were more resistant to the linezolid (2.2%) and daptomycin (9%), respectively. The prevalence of tigecyline-resistant E. facium (1%) strains was higher than E. faecalis strains (0.3%). Accordingly, the prevalence of linezolid-resistant E. faecalis was higher in Asia (2.8%), while linezolid-resistant E. faecium was higher in the America (3.4%). Regarding tigecycline-resistance, a higher prevalence of E. faecalis (0.4%) and E. faecium (3.9%) was reported in Europe.Conclusion: In conclusion, this meta-analysis shows that there is an emerging resistance in Enterococcus strains. Despite the rising resistance of enterococci to antibiotics, our results demonstrate that tigecycline, daptomycin, and linezolid can still be used for the treatment of enterococcal infections worldwide.

【 授权许可】

Unknown