Blood–Brain Barrier Modulation to Improve Glioma Drug Delivery

Pharmaceutics

EricV. Shusta¹  Huilong Luo¹ 

[1] Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA;

关键词: blood–brain barrier;    drug delivery;    glioma;    glioblastoma;    targeting;   

DOI  :  10.3390/pharmaceutics12111085

来源: DOAJ

【 摘 要 】

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The poor BBB penetration of newly developed therapeutics has therefore played a major role in limiting their clinical success. A particularly challenging therapeutic target is glioma, which is the most frequently occurring malignant brain tumor. Thus, to enhance therapeutic uptake in tumors, researchers have been developing strategies to modulate BBB permeability. However, most conventional BBB opening strategies are difficult to apply in the clinical setting due to their broad, non-specific modulation of the BBB, which can result in damage to normal brain tissue. In this review, we have summarized strategies that could potentially be used to selectively and efficiently modulate the tumor BBB for more effective glioma treatment.

【 授权许可】

Unknown