Onset of pulmonary Epstein–Barr virus‐positive diffuse large B‐cell lymphoma in a patient with silicosis

Thoracic Cancer

Saeko Jinnai¹  Takuya Hara¹  Keisuke Iwasaki¹  Hiroshi Mukae²  Hiroyuki Yamaguchi²  Midori Shimada³  Yuichi Fukuda³  Yasuhiro Tanaka³  Hiroshi Soda³  Ryosuke Ogata³  Asuka Umemura³  Masataka Yoshida³  Shota Nakashima³  Koki Yamashita³  Hiroaki Senju³ 

[1] Department of Pathology Sasebo City General Hospital Nagasaki Japan;Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan;Department of Respiratory Medicine Sasebo City General Hospital Nagasaki Japan;

关键词: Epstein–Barr virus;    immune cells;    lymphoma;    silicosis;   

DOI  :  10.1111/1759-7714.14250

来源: DOAJ

【 摘 要 】

Abstract How Epstein–Barr virus (EBV)‐positive diffuse large B‐cell lymphoma (DLBCL) occasionally occurs following chronic inflammation remains to be elucidated. The case of a 57‐year‐old man who developed pulmonary EBV‐positive DLBCL from underlying silicosis lesions is presented. Immunohistochemical examination of the resected silicosis lesions showed predominant helper T cells and M1/M2 macrophages, with a lack of B cells, regulatory T cells, and resident memory T cells. Two years later, EBV‐positive DLBCL emerged unexpectedly from the silicosis. The imbalance of the immune cells in the microenvironment, at least in part, may help explain how chronic inflammation contributes to EBV‐positive DLBCL.

【 授权许可】

Unknown