An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

Frontiers in Oncology

Cristina Stefan¹  Ioana Berindan-Neagoe²  Calin Ionescu³  Adrian Bogdan Tigu⁴  Alina-Andreea Zimta⁴  Cornelia Braicu⁵ 

[1] African Organisation for Research and Training in Cancer, Cape Town, South Africa;Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. I. Chiricuta”, Cluj-Napoca, Romania;Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania;Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania;Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania;Surgical Department, Municipal Hospital, Cluj-Napoca, Romania;

关键词: lncRNAs;    SNHG;    snoRNA;    cancer;    malignant disease;    proliferation;   

DOI  :  10.3389/fonc.2020.00389

来源: DOAJ

【 摘 要 】

The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.

【 授权许可】

Unknown