Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children

Voprosy Sovremennoj Pediatrii

T. N. Stepanova¹  S. G. Makarova¹  T. E. Borovik²  G. V. Yatsyk²  S. G. Gribakin² 

[1] I.M. Sechenov First Moscow State Medical University;Scientific Centre of Children Health, RAMS, Moscow;

关键词: дети;    пищевая аллергия;    сенсибилизация;    кишечный эпителиальный барьер;   

DOI  :  10.15690/vsp.v12i2.615

来源: DOAJ

【 摘 要 】

Intestinal epithelial barrier plays an important role in prevention of bacterial translocation and food allergens penetration. Article is dedicated to intestinal epithelial barrier disfunctions leading to sensitization. Special attention is paid to molecular mechanisms increasing the allergens penetration through intestinal wall. Phase of sensitization is characterized by antigen-induced crossover IgE connection with FcRI receptor on the surface of mast cell which leads to anaphylactic reaction.Key words: infants, food allergy, sensitization, intestinal epithelial barrier.

【 授权许可】

Unknown