期刊论文详细信息
Journal of Functional Foods
Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice
Jianhua Xie1  Xianxiang Chen2  Lixin Huang2  Mingyue Shen2  Yi Chen2  Qiang Yu2 
[1] Corresponding author at: State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, Jiangxi, China.;State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;
关键词: Mesona chinensis Benth;    Sulfated polysaccharide;    Immunomodulatory activity;   
DOI  :  
来源: DOAJ
【 摘 要 】

A sulfated polysaccharide (SMP) from the Mesona chinensis Benth was successfully obtained and its immunomodulatory effects were evaluated. Results showed that SMP exhibited the proliferation effects in splenocytes in vitro and ameliorated the impaired of splenocytes in Cy-treated mice. SMP induced the production of nitric oxide (NO), interleukin (IL) −2, interferon-γ (IFN-γ), increased the expression of antioxidant enzymes (SOD and CAT), and reduced the production of malondialdehyde (MDA) in Cy-treated mice, as well as improved the blood index, body weight and organ index. In addition, SMP enhanced the viability of RAW264.7 macrophages and increased the secretion of IL-6, IL-1β and tumor necrosis factor-α (TNF-α) and production of NO in RAW264.7 cells. Furthermore, SMP binds to TLR4 (Toll-like Receptor 4) to promote RAW264.7 to produce cytokines, thereby exerting immunoregulatory function. These data indicated that SMP act a pivotal part in immunomodulatory and could be used as functional foods.

【 授权许可】

Unknown   

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