A rare case of acute megakaryoblastic leukemia with orbital chloroma in a non-Down syndrome child

Asian Journal of Oncology

Sandeep Jain¹  Gauri Kapoor¹  Sahitya Koneru¹ 

[1] Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India;

关键词: acute megakaryoblastic leukemia;    orbital chloroma;    hyperdiploidy;    immunophenotyping;   

DOI  :  10.4103/2454-6798.209322

来源: DOAJ

【 摘 要 】

Acute megakaryoblastic leukemia (AMKL) is a rare disease accounting for 7%–10% of acute myeloid leukemia (AML) in children. It is uncommon in children without Down syndrome (DS). Orbital chloroma is usually associated with AML M2, M4, and M5. Herein, we report the case of a 22-month-old female who was diagnosed to have AMKL with orbital chloromas and without DS. Morphology and the initial panel of immunophenotyping were inconclusive and the presence of orbital chloromas added to the ambiguity. The presence of CD61 expression and marrow fibrosis supported by hyperdiploidy helped us clinch the diagnosis. Hence, comprehensive analysis of morphology, immunophenotyping, and cytogenetics is warranted to make an accurate diagnosis of AMKL.

【 授权许可】

Unknown