Crepis foetida L. subsp. rhoeadifolia (Bieb.) Celak. as a source of multifunctional agents: Cytotoxic and phytochemical evaluation

Journal of Functional Foods

Mehmet Sefa Kocak¹  Pembegul Uyar²  Abdurrahman Aktumsek³  Cengiz Sarikurkcu⁴  Gokhan Zengin⁵  Ramazan Ceylan⁵  Sengul Uysal⁶ 

[1] Advanced Technology Research and Application Center, Selcuk University, Konya, Turkey;Corresponding author. Faculty of Pharmacy, Department of Analytical Chemistry, Suleyman Demirel University, Isparta 32260, Turkey. Tel.: [phone];fax: [phone].;Faculty of Pharmacy, Department of Analytical Chemistry, Suleyman Demirel University, Isparta, Turkey;Faculty of Science, Department of Biology, Selcuk University, Konya, Turkey;Faculty of Science, Department of Biotechnology, Selcuk University, Konya, Turkey;

关键词: Crepis foetida subsp. rhoeadifolia;    Antiproliferative;    Anticholinesterase;    Antityrosinase;    Antioxidant effects;   

DOI  :  

来源: DOAJ

【 摘 要 】

The cytotoxic, anticholinesterase, antityrosinase and antioxidant effects of methanol extract from the flower of C. foetida subsp. rhoeadifolia (CFRME) were evaluated. The cytotoxic effect was investigated using HepG2, Caco-2, MCF-7 and MCF-10A cell lines. Enzyme inhibitory activities were tested by spectrophotometric methods. Different chemical assays were used to determine the antioxidant effects. In addition, phenolic constituents were quantified. High-performance liquid chromatographic (HPLC) analysis revealed that chlorogenic acid was the major phenolic component in the extract. The extract showed a strong antiproliferative, antioxidant, and anticholinesterase and antityrosinase effects. These findings suggest that C. foetida subsp. rhoeadifolia may be considered as a source of ingredients that can be used as food supplements.

【 授权许可】

Unknown