HuR Protein in Hepatocellular Carcinoma: Implications in Development, Prognosis and Treatment

Biomedicines

Alexandros Pergaris¹  Panagiotis Sarantis¹  Vasiliki Papatheofani¹  Georgia Levidou¹  Stamatios Theocharis¹  Evangelos Koustas²  MichalisV. Karamouzis²  Gregorios Kouraklis³ 

[1] First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;Second Department of Propedeutic Surgery, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;

关键词: HuR;    HCC;    ELAV;    HSC;   

DOI  :  10.3390/biomedicines9020119

来源: DOAJ

【 摘 要 】

Hu-antigen R (HuR) is a post-transcriptional regulator that belongs to the embryonic lethal abnormal vision Drosophila-like family (ELAV). HuR regulates the stability, translation, subcellular localization, and degradation of several target mRNAs, which are implicated in carcinogenesis and could affect therapeutic options. HuR protein is consistently highly expressed in hepatocellular carcinoma (HCC) compared to the adjacent normal liver tissue and is involved in the post-transcriptional regulation of various genes implicated in liver malignant transformation. Additionally, HuR protein seems to be a putative prognosticator in HCC, predicting worse survival. This review summarizes the recent evidence regarding the role of HuR in primary liver tumors, as presented in clinical studies, in vitro experiments and in vivo animal models. In conclusion, our review supports the consistent role of HuR protein in the development, prognosis, and treatment of HCC. Additional studies are expected to expand current information and exploit its putative employment as a future candidate for more personalized treatment in these tumors.

【 授权许可】

Unknown