Tackling HLA Deficiencies Head on with Oncolytic Viruses

Cancers

Ahmet Hazini¹  LeonardW. Seymour¹  Kerry Fisher¹ 

[1] Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK;

关键词: oncolytic virus;    class I HLA;    immunosurveillance;    immunotherapy;   

DOI  :  10.3390/cancers13040719

来源: DOAJ

【 摘 要 】

Dysregulation of HLA (human leukocyte antigen) function is increasingly recognized as a common escape mechanism for cancers subject to the pressures exerted by immunosurveillance or immunotherapeutic interventions. Oncolytic viruses have the potential to counter this resistance by upregulating HLA expression or encouraging an HLA-independent immunological responses. However, to achieve the best therapeutic outcomes, a prospective understanding of the HLA phenotype of cancer patients is required to match them to the characteristics of different oncolytic strategies. Here, we consider the spectrum of immune competence observed in clinical disease and discuss how it can be best addressed using this novel and powerful treatment approach.

【 授权许可】

Unknown