Tadalafil significantly reduces ischemia reperfusion injury in skin island flaps

Indian Journal of Plastic Surgery

Ugur Kocer¹  Oguz Kayiran²  Suat S. Cuzdan³  Afsin Uysal⁴ 

[1] Ankara Training and Research Hospital, Ankara, Turkey;Department of Plastic and Reconstructive Surgery Clinic, Izmir Ekol KBB Hospital;Sanmed Hospital, Sanliurfa;TOBB ETU Hospital;

关键词: free radicals;    ischemia;    island flap;    reperfusion injury;    tadalafil;   

DOI  :  10.4103/0970-0358.113714

来源: DOAJ

【 摘 要 】

Introduction: Numerous pharmacological agents have been used to enhance the viability of flaps. Ischemia reperfusion (I/R) injury is an unwanted, sometimes devastating complication in reconstructive microsurgery. Tadalafil, a specific inhibitor of phosphodiesterase type 5 is mainly used for erectile dysfunction, and acts on vascular smooth muscles, platelets and leukocytes. Herein, the protective and therapeutical effect of tadalafil in I/R injury in rat skin flap model is evaluated. Materials and Methods: Sixty epigastric island flaps were used to create I/R model in 60 Wistar rats (non-ischemic group, ischemic group, medication group). Biochemical markers including total nitrite, malondialdehyde (MDA) and myeloperoxidase (MPO) were analysed. Necrosis rates were calculated and histopathologic evaluation was carried out. Results: MDA, MPO and total nitrite values were found elevated in the ischemic group, however there was an evident drop in the medication group. Histological results revealed that early inflammatory findings (oedema, neutrophil infiltration, necrosis rate) were observed lower with tadalafil administration. Moreover, statistical significance (P < 0.05) was recorded. Conclusions: We conclude that tadalafil has beneficial effects on epigastric island flaps against I/R injury.

【 授权许可】

Unknown