期刊论文详细信息
Beilstein Journal of Organic Chemistry | |
Copper-promoted hydration and annulation of 2-fluorophenylacetylene derivatives: from alkynes to benzo[b]furans and benzo[b]thiophenes | |
Xiaohang Liu1  Liang Cheng2  Ning Sun2  Yibiao Li2  Bin Li2  | |
[1] BASF Catalyst, 23800 Mercantile Road, Beachwood, Ohio 44124, USA;School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, Guangdong Province, 529090, China; | |
关键词: annulation; benzo[b]furan; C–F activation; copper-promoted; heterocycle; | |
DOI : 10.3762/bjoc.10.305 | |
来源: DOAJ |
【 摘 要 】
An efficient copper-promoted hydration reaction and its application in the synthesis of benzo[b]furan and benzo[b]thiophene derivatives is presented starting from readily available 2-fluorophenylacetylene derivatives. The key annulation step involves the hydration of the C–F bond of 2-fluorophenylacetylene derivatives followed by an intramolecular annulation to afford benzo[b]furan and benzo[b]thiophene derivatives. Moreover, structurally important 2,2'-bisbenzofuran scaffolds are provided in good yields.
【 授权许可】
Unknown