Role of Circular RNA in Kidney-Related Diseases

Frontiers in Pharmacology

Xin-Tian Chen¹  Su-Fang Chu¹  Xue Zhao¹  Ping-Fu Hou²  Zhong-Wei Li²  Jun-Nian Zheng²  Min-Le Li²  Jin Bai² 

[1] Cancer Institute, Xuzhou Medical University, Xuzhou, China;Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;

关键词: circRNAs;    renal cell carcinoma;    acute kidney injury;    chronic kidney diseases;    EMT;   

DOI  :  10.3389/fphar.2021.615882

来源: DOAJ

【 摘 要 】

The kidney is vital in maintaining fluid, electrolyte, and acid–base balance. Kidney-related diseases, which are an increasing public health issue, can happen to people of any age and at any time. Circular RNAs (circRNAs) are endogenous RNA that are produced by selective RNA splicing and are involved in progression of various diseases. Studies have shown that various kidney diseases, including renal cell carcinoma, acute kidney injury, and chronic kidney disease, are linked to circRNAs. This review outlines the characteristics and biological functions of circRNAs and discusses specific studies that provide insights into the function and potential of circRNAs for application in the diagnosis and treatment of kidney-related diseases.

【 授权许可】

Unknown