期刊论文详细信息
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Combined Salt and Caloric Restrictions: Potential Adverse Outcomes
Mika Homma1  Korapat Mayurasakorn1  Nurul Mahamad Rodi1  Tham Yao1  Shelley Hurwitz1  Gail K. Adler1  Gordon H. Williams1  Anis Amalina Abdul Hamid1  Jose R. Romero1  Luminita H. Pojoga1  Tsuyoshi Homma1  Yuefei Huang1 
[1] Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA;
关键词: aldosterone;    blood pressure;    caloric restriction;    high blood pressure;    hypertension;    insulin action;   
DOI  :  10.1161/JAHA.116.005374
来源: DOAJ
【 摘 要 】

BackgroundWe hypothesized that caloric restriction (CR) and salt restriction (ResS) would have similar effects on reducing cardiovascular risk markers and that combining CR and ResS would be synergistic in modulating these markers. Methods and ResultsTo test our hypothesis, rats were randomized into 2 groups: ad libitum liberal salt diet (ad libitum/high‐sodium, 1.6% sodium) or ResS diet (ad libitum/ResS, 0.03% sodium). CR was initiated in half of the rats in each group by reducing caloric intake to 60% while maintaining sodium intake constant (CR/high‐sodium, 2.7% sodium or CR/ResS, 0.05% sodium) for 4 weeks. CR in rats on a high‐sodium diet improved metabolic parameters, renal transforming growth factor‐β and collagen‐1α1 and increased plasma adiponectin and renal visfatin and NAD+ protein levels. Although CR produced some beneficial cardiovascular effects (increased sodium excretion and reduced blood pressure), it also was associated with potentially adverse cardiovascular effects. Adrenal zona glomerulosa cell responsiveness and aldosterone levels and activation were inappropriately increased for the volume state of the rodent. Like CR on HS, CR on a ResS diet also produced relative increased zona glomerulosa responsiveness and an increased blood pressure with no improvement in metabolic parameters. ConclusionsThese results suggest that combining CR and ResS may decrease the beneficial effects of each alone. Furthermore, CR, regardless of dietary salt intake, inappropriately activates aldosterone production. Thus, caution should be used in combining ResS and CR because the combination may lead to increased cardiovascular risk.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次