期刊论文详细信息
eLife
Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
Jennifer C Regan1  Nattaphong Rattanavirotkul1  Linda Partridge1  Mobina Khericha1  Adam J Dobson1  Ekin Bolukbasi1 
[1] Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom;
关键词: ageing;    intestine;    immunity;    sex;    stem cells;    gut;   
DOI  :  10.7554/eLife.10956
来源: DOAJ
【 摘 要 】

Women live on average longer than men but have greater levels of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila. The intestinal epithelium of the aging female undergoes major deterioration, driven by intestinal stem cell (ISC) division, while lower ISC activity in males associates with delay or absence of pathology, and better barrier function, even at old ages. Males succumb to intestinal challenges to which females are resistant, associated with fewer proliferating ISCs, suggesting a trade-off between highly active repair mechanisms and late-life pathology in females. Dietary restriction reduces gut pathology in aging females, and extends female lifespan more than male. By genetic sex reversal of a specific gut region, we induced female-like aging pathologies in males, associated with decreased lifespan, but also with a greater increase in longevity in response to dietary restriction.

【 授权许可】

Unknown   

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