The Distribution and Prevalence of High-Risk HPV Genotypes Other than HPV-16 and HPV-18 among Women Attending Gynecologists’ Offices in Kazakhstan

Biology

Torgyn Issa¹  Azliyati Azizan¹  Chee Kai Chan¹  Gulzhanat Aimagambetova¹  Aisha Babi¹  Alpamys Issanov²  Zhuldyz Abakasheva³  Zhanna Sattarkyzy⁴  Natalya Udalova⁵  Sholpan Akhanova⁶  Svetlana Koktova⁷  Askhat Balykov⁷ 

[1] Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan;Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan;Gynecology Department, Daliya Clinic, Pavlodar 140013, Kazakhstan;Obstetrics and Gynecology Department, City polyclinic 6, Nur-Sultan 010000, Kazakhstan;Obstetrics and Gynecology Department, East Kazakhstan Regional Hospital, Oskemen 07000, Kazakhstan;Obstetrics and Gynecology Department, Keruen Medicus Clinic, Almaty 050040, Kazakhstan;Regional Perinatal Center, Altynsarin 3, Aktobe 030006, Kazakhstan;

关键词: cervical cancer;    HPV;    high-risk HPV;    HPV epidemiology;    Kazakhstan;   

DOI  :  10.3390/biology10080794

来源: DOAJ

【 摘 要 】

Cervical cancer represents a great burden to public health of women. This study aimed to obtain a nationwide genotyping survey and analysis of high risk-HPV including those that are caused by HPV types other than HPV-16 and HPV-18, among women in Kazakhstan. This study was conducted based on the collection of survey and cervical swabs of 1645 women across the country. The samples were genotyped for high-risk HPV types based on real-time PCR methods. Collected data was analyzed with the focus on high-risk HPV types other than HPV-16 and -18. Infection was present in 22% of women who participated in the study. The most prevalent types were HPV-31 among single infections and HPV-68 among multiple infections. Conclusively, despite the lack of attention high-risk HPV types beyond HPV-16 and -18 get in attempts of cervical cancer prevention in Kazakhstan, their prevalence is high and plays a large role in cervical cancer epidemiological situation.

【 授权许可】

Unknown